Seong Su Kang Selected Research

asparaginylendopeptidase (legumain)

1/2022	Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase.
1/2021	A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies.
1/2021	C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
1/2020	Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease.
1/2018	BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
1/2018	α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
8/2017	Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.
1/2017	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
11/2014	Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

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Seong Su Kang Research Topics

Disease

13	Alzheimer Disease (Alzheimer's Disease) 08/2022 - 11/2014
10	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2017
6	Cognitive Dysfunction 08/2022 - 01/2021
4	Inflammation (Inflammations) 01/2021 - 01/2013
3	Motor Disorders 01/2022 - 11/2019
3	Amyloid Plaque 01/2022 - 01/2021
3	Constipation 12/2021 - 01/2020
3	Stroke (Strokes) 10/2013 - 07/2012
2	Neoplasms (Cancer) 01/2021 - 10/2020
2	Synucleinopathies 08/2017 - 01/2017
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2013 - 07/2012
2	Ischemia 07/2012 - 09/2008
1	Insulin Resistance 08/2022
1	Peripheral Nerve Injuries 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Prodromal Symptoms 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 10/2020
1	Dysbiosis 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Astrocytoma (Pilocytic Astrocytoma) 05/2013
1	Brain Ischemia (Cerebral Ischemia) 01/2013
1	Hypoxia (Hypoxemia) 07/2012
1	Infarction (Infarctions) 09/2008
1	Hypertension (High Blood Pressure) 12/2007

Drug/Important Bio-Agent (IBA)

9	asparaginylendopeptidase (legumain)IBA 01/2022 - 11/2014
8	SynucleinsIBA 01/2021 - 01/2017
7	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022 - 01/2017
6	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022 - 10/2013
5	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2017
4	Netrin-1IBA 01/2022 - 01/2021
4	Ciliary Neurotrophic Factor (CNTF)IBA 10/2013 - 07/2012
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2017
3	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2018
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 01/2021
2	Apolipoprotein E4IBA 01/2022 - 01/2021
2	ProdrugsIBA 01/2022 - 01/2018
2	Netrin ReceptorsIBA 01/2021 - 01/2020
2	RotenoneIBA 01/2021 - 01/2020
2	NeurotoxinsIBA 01/2020 - 11/2019
2	Dopamine (Intropin)FDA LinkGeneric 11/2019 - 01/2018
1	LipopolysaccharidesIBA 08/2022
1	Insulin (Novolin)FDA Link 08/2022
1	LigandsIBA 01/2022
1	Follicle Stimulating Hormone (Follitropin)FDA Link 01/2022
1	NetrinsIBA 01/2022
1	CholesterolIBA 01/2022
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2021
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021
1	Apolipoprotein E3IBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	DCC ReceptorIBA 01/2021
1	CCAAT-Enhancer-Binding Protein-betaIBA 01/2021
1	AsparagineIBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	CytokinesIBA 01/2021
1	Small Interfering RNA (siRNA)IBA 10/2020
1	3-nitrophenyl 3-piperidinecarboxylate (MNPC)IBA 10/2020
1	ErbB Receptors (EGF Receptor)IBA 10/2020
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2019
1	lysosomal asparaginyl endopeptidaseIBA 01/2018
1	Monoamine Oxidase (MAO)IBA 01/2018
1	6,7-dihydroxyflavoneIBA 01/2018
1	Cysteine Proteases (Cysteine Protease)IBA 01/2017
1	Pharmaceutical PreparationsIBA 10/2013
1	Purinergic P2X7 ReceptorsIBA 10/2013
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 10/2013
1	Nerve Growth Factors (Neurotrophins)IBA 10/2013
1	Fibronectins (Fibronectin)IBA 05/2013
1	Laminin (Merosin)IBA 05/2013
1	VitronectinIBA 05/2013
1	Fibrinogen (Factor I)FDA Link 05/2013
1	ThrombospondinsIBA 05/2013
1	IntegrinsIBA 05/2013
1	CollagenIBA 05/2013
1	SolutionsIBA 07/2012
1	Rose BengalIBA 09/2008
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 09/2008
1	Matrix Metalloproteinases (MMPs)IBA 09/2008
1	4- aminobenzoyl- glycyl- prolyl- leucyl- alanine hydroxamic acidIBA 09/2008
1	Matrix Metalloproteinase InhibitorsIBA 09/2008
1	NestinIBA 09/2008
1	SaltsIBA 12/2007
1	Desoxycorticosterone (Deoxycorticosterone)IBA 12/2007
1	Oxidoreductases (Dehydrogenase)IBA 12/2007
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 12/2007
1	AldosteroneIBA 12/2007
1	Acetates (Acetic Acid Esters)FDA Link 12/2007
1	Desoxycorticosterone Acetate (DOCA)FDA Link 12/2007
1	SodiumIBA 12/2007

Therapy/Procedure

2	Oral Administration 12/2021 - 01/2020
1	Therapeutics 01/2022
1	Surgical Instruments (Clip) 12/2007